Biotransformation and toxicity of inhalational anaesthetics

Biotransformation and toxicity of inhalational anaesthetics.

In summary, anaesthetics and drugs used perioperatively are all xenobiotics and can be metabolized mainly by microsomal enzyme systems, which have a high activity in the liver. These enzyme systems are induced by repeated pre-administration of drugs, such as barbiturates and others which are used during the preoperative period. However, according to some reports, aerobic and anaerobic metabolis...

Nephrotoxicity of halogenated inhalational anaesthetics: fictions and facts.

The effect of inhalational anaesthetics on the microtubular system in Actinosphaerium nucleofilum.

Six different anaesthetic agents were found to cause reversible collapse of the axopods of Actinosphaerium nucleofilum. The effect occurred at concentrations proportional to those required to anaesthetize man. Electron microscopy showed dispersal of the microtubular system and disaggregation of the microtubules of the axonemes, and expanded microtubules without interlinkage were seen in the rel...

Intestinal obstruction in acute inhalational toluene 2,4-diisocyanate gas toxicity.

The isocyanates are widely used as precursors of polyurethane products, as well as carbamate insecticides. Toluene 2,4-diisocyanate (TDI) is one of the most important commercially used isocyanates. Humans may be exposed to TDI by inhalation, ingestion, dermal and eye contact. TDI is a powerful irritant to the mucosal membranes of the gastrointestinal and respiratory tracts, eyes and the skin. P...

Biotransformation of Hydrazine Dervatives in the Mechanism of Toxicity

Hydrazine derivatives are environmental and food pollutants but are also important because of their use in medicine for the treatment of tuberculosis and cancer. However, hydrazines also pose significant health risks to humans as they are mutagenic and carcinogenic. This review examines various metabolic pathways (enzymatic and non-enzymatic) of hydrazines for the formation of reactive species ...